First Covid-19 Vaccine code-named mRNA-1273 Shot Given

At a news conference, President Donald Trump praised how quickly the research had progressed. Fauci noted that 65 days have passed since Chinese scientists shared the virus’ genetic sequence. He said he believed that was a record for developing a vaccine to test.

Seattle: This vaccine candidate, code-named mRNA-1273, was developed by the NIH and Massachusetts-based biotechnology company Moderna Inc. There’s no chance participants could get infected because the shots do not contain the coronavirus itself.

It’s not the only potential vaccine in the pipeline. Dozens of research groups around the world are racing to create a vaccine against COVID-19. Another candidate, made by Inovio Pharmaceuticals, is expected to begin its own safety study next month in the U.S., China and South Korea.

The Seattle experiment got underway days after the World Health Organization declared the new virus outbreak a pandemic because of its rapid global spread, which has infected more than 169,000 people and killed more than 6,500. AP reporter(s) witnessed the first human trial on Monday.

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Other medical procedures are underway in hundreds of forms to combat the Covid-19 outbreak.

A very old drug developed by a scientist in 1934 for Bayer discovered chloroquine for malaria. It was widely used during World War ll and has been extensively used for SARS with excellent results. Its history goes back to Peru (South America), where the indigenous people extracted the bark of the Cinchona trees and used the extract (Chinchona officinalis) to fight chills and fever in the seventeenth century. In 1633 this herbal medicine was introduced in Europe, where it was given the same use and also began to be used against malaria.

We report on chloroquine, a 4-amino-quinoline, as an effective inhibitor of the replication of the severe acute respiratory syndrome coronavirus (SARS-CoV) in vitro. Chloroquine is a clinically approved drug effective against malaria.

It was reported a few weeks ago that officials in China were not cooperating with other nations at the outset of Covid-19. That is only partially true. The U.S. has collaborated with scientists and medical experts in China since SARS and continues to do so with very positive results.

Data from the drug’s studies showed ‘certain curative effect’ with ‘fairly good efficacy’.

According to Sun, patients treated with chloroquine demonstrated a better drop in fever, improvement of lung CT images, and required a shorter time to recover compared to parallel groups.

The percentage of patients with negative viral nucleic acid tests was also higher with the anti-malarial drug.

Chloroquine has so far showed no obvious serious adverse reactions in the more than 100 participants in the trials.

The China National Center for Biotechnology Development head Zhang Xinmin said that chloroquine is one of the three drugs that have a promising profile against the new coronavirus, reported China Daily.

The remaining two drugs are anti-flu medicine favipiravir and Gilead’s investigational anti-viral candidate remdesivir.

Favipiravir is currently in a 70-patient trial in Shenzhen, Guangdong province, while remdesivir is under evaluation at more than ten medical institutions in Wuhan.

In trials conducted in China, chloroquine appears to be useful for coronavirus disease 2019. Another form is Hydroxychloroquine.

Hydroxychloroquine is also presecribed for HIV, arthritis as well as advanced malaria and strains of coronavirus. It is a disease-modifying anti-rheumatic drug (DMARD).It regulates the activity of the immune system, which may be overactive in some conditions.

A small 40 cents, that is $.40 a dose to make and is generally sold for $5.00 per dose.