FBI Abuse of FISA Much Worse per New Report

Posted on March 31, 2020March 31, 2020 by Denise Simon

FBI problems with FISA warrants extend beyond Russia case, DOJ watchdog warns

The Justice Department’s chief watchdog issued an extraordinary warning Tuesday that the FBI is failing to follow its own rules when pursuing surveillance warrants in sensitive intelligence and terrorism cases, confirming that problems first exposed in the Russia collusion probe extend to other cases.

Among the problems cited was a failure by agents to substantiate allegations submitted to courts, similar to the missteps the FBI made in failing to ensure allegations in the Steele dossier back in 2016 were verified before securing a FISA warrant targeting the Trump campaign and former adviser Carter Page.

The report found that investigators:

could not review original Woods Files for four of the 29 selected FISA applications because the FBI has not been able to locate them and, in 3 of these instances, did not know if they ever existed;

identified apparent errors or inadequately supported facts in all of the 25 applications we reviewed;

identified deficiencies in documentary support and application accuracy;

interviewed FBI officials who indicated to us that there were no efforts by the FBI to use existing FBI and National Security Division oversight mechanisms to perform comprehensive, strategic assessments of the efficacy of the Woods Procedures or FISA accuracy.

Sen. Charles Grassley, R-Iowa, a senior member of the Judiciary Committee who played a key role in exposing FISA abuses during the Russia probe, said Horowitz’s memo show the problems first exposed with the faulty Carter Page warrant were “just the tip of the iceberg.”

“Not a single application from the past five years reviewed by the inspector general was up to snuff. That’s alarming and unacceptable,” Grassley said.

“The FBI has an important job to protect our national security, but it does not have carte blanche to routinely erode the liberties of Americans without proper justification. Oversight mechanisms like the Woods Procedures exist for a reason, and if the FBI wants to restore its reputation among the American people, it had better start taking them seriously,” he added.

source

The final report just issued in .pdf is found here.

Additionally, NR has this summary in part:

Horowitz’s office said in a report released Tuesday that of the 29 applications — all of which involved U.S. citizens – that were pulled from “8 FBI field offices of varying sizes,” the FBI could not find Woods Files for four of the applications, while the other 25 all had “apparent errors or inadequately supported facts.”

“While our review of these issues and follow-up with case agents is still ongoing—and we have not made materiality judgments for these or other errors or concerns we identified—at this time we have identified an average of about 20 issues per application reviewed, with a high of approximately 65 issues in one application and less than 5 issues in another application,” the report reveals.

The Woods Procedure dictates that the Justice Department verify the accuracy and provide evidentiary support for all facts stated in its FISA application. The FBI is required to share with the FISA Court all relevant information compiled in the Woods File when applying for a surveillance warrant.

“FBI and NSD officials we interviewed indicated to us that there were no efforts by the FBI to use existing FBI and NSD oversight mechanisms to perform comprehensive, strategic assessments of the efficacy of the Woods Procedures or FISA accuracy, to include identifying the need for enhancements to training and improvements in the process, or increased accountability measures,” the report states.

The OIG concludes by recommending that the FBI “systematically and regularly examine the results of past and future accuracy reviews to identify patterns or trends in identified errors” relating to the Woods Procedure, as well as double-checking “that Woods Files exist for every FISA application submitted to the FISC in all pending investigations.”

In a letter acknowledging the audit, FBI Associate Deputy Director Paul Abbate said that the issues “will be addressed” by the Bureau’s already-issued correctives after the Carter Page review, and added that “the FBI fully accepts the two recommendations.”

McCabe admitted in January that the FBI has an “inherent weakness in the process” of obtaining FISA warrants.

China Supplied Faulty Coronavirus Test Kits

Posted on March 26, 2020March 26, 2020 by Denise Simon

Seems to be a systemic problem with China as in 2017, the Chinese Communist Party issued a sizable medical equipment recall for faulty quality. It is unclear just what equipment was included but the CCP said they would reissue equipment under tighter controls. Swell.

China Supplied Faulty Coronavirus Test Kits to Spain, Czech Republic source

Translated from El Pais newspaper:

The much-announced rapid tests for coronaviruses with which the Government wanted to start testing the broader layers of the population to find out what is the real size of the contagion in Spain do not work well. This has been confirmed by several microbiology laboratories of large hospitals in the analyzes that have been made of the kits recently arrived from China. The results of these preliminary tests are discouraging: “They do not detect the positive cases as expected,” says a source who has participated in the tests and who asks for anonymity.

The rapid tests, manufactured by the Chinese company Bioeasy, based in Shenzhen, one of the technological poles of the Asian country, have a sensitivity of 30%, when it should be above 80%, these sources indicate. One of the microbiologists who has analyzed the Chinese test assures: “With that value it does not make sense to use these tests.” The conclusion of the experts who have evaluated these detection kits is that they will have to continue using the current test, the PCR. This has been reported to the Carlos III Health Institute, under the Ministry of Health.

The price of the sale of Chinese medical equipment to Spain was $467 million. In the transaction of medical equipment was 950 ventilators, 5.5 million testing kits and 11 million gloves and 500 million protective face masks. Chinese blamed one of its own companies called Bioesy and declared the company was not licensed. Okay, sure Beijing.

***

From NR:

Up to 80 percent of the 150,000 portable, quick coronavirus test kits China delivered to the Czech Republic earlier this month were faulty, according to local Czech news site Expats.cz. The tests can produce a result in 10 or 15 minutes but are usually less accurate than other tests. Because of the high error rate, the country will continue to rely on conventional laboratory tests, of which they perform about 900 a day.

The country’s Health Ministry paid $546,000 for 100,000 of the test kits, while the Interior Ministry paid for the other 50,000.

Deputy Prime Minister and Interior Minister Jan Hamacek downplayed the discovery that many of the tests were faulty, blaming it on a possible wrong methodology and saying the kits can still be used “when the disease has been around for some time,” or when “someone returns after quarantine after fourteen days.”

“In my opinion, this is not about some scandalous revelation that it is not working,” Hamacek said.

Meanwhile, Spain, which has more than 56,000 infected people and more than 4,000 coronavirus deaths, the second-highest number of fatalities in the world after Italy, found that the rapid coronavirus test kits it purchased from Chinese company Bioeasy only correctly identified 30 percent of virus cases, according to Spanish newspaper El Pais.

The director Spain’s Center for Health Alerts and Emergencies, Fernando Simón, said Spain tested 9,000 of the test kits and will return them based on their high error rate.

Studies performed on the tests which discovered the high error rate caused the Spanish Society of Infectious Diseases and Clinical Microbiology to recommend officially that the tests not be used.

The Chinese embassy in Spain claimed the Bioeasy products are not included in the products China has been supplying to countries where the virus has broken out.

source

Spain has 49,515 confirmed cases and there have been so many deaths in one small town, the officials had to use an ice skating rink to hold the bodies for burial processing.

Nicolás Maduro,14 Other Officials Charged with Narco-Terrorism, Corruption

Posted on March 26, 2020March 26, 2020 by Denise Simon

Department of Justice
Office of Public Affairs
FOR IMMEDIATE RELEASE

Venezuelan Officials Say President Nicolás Maduro Is ... source
Thursday, March 26, 2020
Nicolás Maduro Moros and 14 Current and Former Venezuelan Officials Charged with Narco-Terrorism, Corruption, Drug Trafficking and Other Criminal Charges
Maduro and Other High Ranking Venezuelan Officials Allegedly Partnered With the FARC to Use Cocaine as a Weapon to “Flood” the United States

Former President of Venezuela Nicolás Maduro Moros, Venezuela’s vice president for the economy, Venezuela’s Minister of Defense, and Venezuela’s Chief Supreme Court Justice are among those charged in New York City; Washington, DC; and Miami, along with current and former Venezuelan government officials as well as two Fuerzas Armadas Revolucionarias de Colombia (FARC) leaders, announced U.S. Attorney General William P. Barr, U.S. Attorney Geoffrey S. Berman of the Southern District of New York, U.S. Attorney Ariana Fajardo Orshan of the Southern District of Florida, Assistant Attorney General Brian A. Benczkowski of the Justice Department’s Criminal Division, Acting Administrator Uttam Dhillon of the U.S. Drug Enforcement Administration (DEA) and Acting Executive Associate Director Alysa D. Erichs of U.S. Immigration and Customs Enforcement’s Homeland Security Investigations (HSI).

“The Venezuelan regime, once led by Nicolás Maduro Moros, remains plagued by criminality and corruption,” said Attorney General Barr. “For more than 20 years, Maduro and a number of high-ranking colleagues allegedly conspired with the FARC, causing tons of cocaine to enter and devastate American communities. Today’s announcement is focused on rooting out the extensive corruption within the Venezuelan government – a system constructed and controlled to enrich those at the highest levels of the government. The United States will not allow these corrupt Venezuelan officials to use the U.S. banking system to move their illicit proceeds from South America nor further their criminal schemes.”

“Today we announce criminal charges against Nicolás Maduro Moros for running, together with his top lieutenants, a narco-terrorism partnership with the FARC for the past 20 years,” said U.S. Attorney Geoffrey S. Berman. “The scope and magnitude of the drug trafficking alleged was made possible only because Maduro and others corrupted the institutions of Venezuela and provided political and military protection for the rampant narco-terrorism crimes described in our charges. As alleged, Maduro and the other defendants expressly intended to flood the United States with cocaine in order to undermine the health and wellbeing of our nation. Maduro very deliberately deployed cocaine as a weapon. While Maduro and other cartel members held lofty titles in Venezuela’s political and military leadership, the conduct described in the Indictment wasn’t statecraft or service to the Venezuelan people. As alleged, the defendants betrayed the Venezuelan people and corrupted Venezuelan institutions to line their pockets with drug money.”

“Over the last decade, corrupt Venezuelan government officials have systematically looted Venezuela of billions of dollars,” said U.S. Attorney Ariana Fajardo Orshan. “Far too often, these corrupt officials and their co-conspirators have used South Florida banks and real estate to conceal and perpetuate their illegal activity. As the recent charges show, Venezuelan corruption and money laundering in South Florida extends to even the highest levels of Venezuela’s judicial system. In the last couple of years, the US Attorney’s Office in South Florida and its federal law enforcement partners have united to bring dozens of criminal charges against high-level regime officials and co-conspirators resulting in seizures of approximately $450 million dollars.”

“These indictments expose the devastating systemic corruption at the highest levels of Nicolas Maduro’s regime,” said DEA Acting Administrator Uttam Dhillon. “These officials repeatedly and knowingly betrayed the people of Venezuela, conspiring, for personal gain, with drug traffickers and designated foreign terrorist organizations like the FARC. Today’s actions send a clear message to corrupt officials everywhere that no one is above the law or beyond the reach of U.S. law enforcement. The Department of Justice and the Drug Enforcement Administration will continue to protect the American people from ruthless drug traffickers – no matter who they are or where they live.”

“The collaborative nature of this investigation is representative of the ongoing work HSI and international law enforcement agencies perform each day, often behind the scenes and unknown to the public, to make our communities safer and free from corruption,” said HSI’s Acting Executive Associate Director Alysa D. Erichs. “Today’s announcement highlights HSI’s global reach and commitment to aggressively identify, target and investigate individuals who violate U.S. laws, exploit financial systems, and hide behind cryptocurrency to further their illicit criminal activity. Let this indictment be a reminder that no one is above the law – not even powerful political officials.”

A four-count superseding indictment unsealed today in the Southern District of New York (SDNY) charges Nicolás Maduro Moros, 57; Diosdado Cabello Rondón, 56, head of Venezuela’s National Constituent Assembly; Hugo Armando Carvajal Barrios aka “El Pollo,” 59, former director of military intelligence; Clíver Antonio Alcalá Cordones, 58, former General in the Venezuelan armed forces; Luciano Marín Arango aka “Ivan Marquez,” 64, a member of the FARC’s Secretariat, which is the FARC’s highest leadership body; and Seuxis Paucis Hernández Solarte aka “Jesús Santrich,” 53, a member of the FARC’s Central High Command, which is the FARC’s second-highest leadership body. The case is pending before U.S. District Judge Alvin K. Hellerstein.

The U.S. Department of State, through its Narcotics Rewards Program, is offering rewards of up to $15 million for information leading to the arrest and/or conviction of Maduro Moros, up to $10 million for information leading to the arrest and/or conviction of Cabello Rondón, Carvajal Barrios, and Alcalá Cordones, and up to $5 million for information leading to the arrest and/or conviction of Marín Arango.

Maduro Moros, Cabello Rondón, Carvajal Barrios, Alcalá Cordones, Marín Arango, and Hernández Solarte have each been charged with: (1) participating in a narco-terrorism conspiracy, which carries a 20-year mandatory minimum sentence and a maximum of life in prison; (2) conspiring to import cocaine into the United States, which carries a 10-year mandatory minimum sentence and a maximum of life in prison; (3) using and carrying machine guns and destructive devices during and in relation to, and possessing machine guns and destructive devices in furtherance of, the narco-terrorism and cocaine-importation conspiracies, which carries a 30-year mandatory minimum sentence and a maximum of life in prison; and (4) conspiring to use and carry machine guns and destructive devices during and in relation to, and to possess machine guns and destructive devices in furtherance of, the narco-terrorism and cocaine-importation conspiracies, which carries a maximum sentence of life in prison. The potential mandatory minimum and maximum sentences in this case are prescribed by Congress and provided here for informational purposes only, as any sentencing of the defendants will be determined by the judge.

According to the allegations contained in the superseding indictment, other court filings, and statements made during court proceedings:

Since at least 1999, Maduro Moros, Cabello Rondón, Carvajal Barrios and Alcalá Cordones, acted as leaders and managers of the Cártel de Los Soles, or “Cartel of the Suns.” The Cartel’s name refers to the sun insignias affixed to the uniforms of high-ranking Venezuelan military officials. Maduro Moros and the other charged Cartel members abused the Venezuelan people and corrupted the legitimate institutions of Venezuela—including parts of the military, intelligence apparatus, legislature, and the judiciary—to facilitate the importation of tons of cocaine into the United States. The Cártel de Los Soles sought to not only enrich its members and enhance their power, but also to “flood” the United States with cocaine and inflict the drug’s harmful and addictive effects on users in the United States.

Marín Arango and Hernández Solarte are leaders of the FARC. Beginning in approximately 1999, while the FARC was purporting to negotiate toward peace with the Colombian government, FARC leaders agreed with leaders of the Cártel de Los Soles to relocate some of the FARC’s operations to Venezuela under the protection of the Cartel. Thereafter, the FARC and the Cártel de Los Soles dispatched processed cocaine from Venezuela to the United States via transshipment points in the Caribbean and Central America, such as Honduras. By approximately 2004, the U.S. Department of State estimated that 250 or more tons of cocaine were transiting Venezuela per year. The maritime shipments were shipped north from Venezuela’s coastline using go-fast vessels, fishing boats, and container ships. Air shipments were often dispatched from clandestine airstrips, typically made of dirt or grass, concentrated in the Apure State. According to the U.S. Department of State, approximately 75 unauthorized flights suspected of drug-trafficking activities entered Honduran airspace in 2010 alone, using what is known as the “air bridge” cocaine route between Venezuela and Honduras.

In his role as a leader of the Cártel de Los Soles, Maduro Moros negotiated multi-ton shipments of FARC-produced cocaine; directed that the Cártel de Los Soles provide military-grade weapons to the FARC; coordinated foreign affairs with Honduras and other countries to facilitate large-scale drug trafficking; and solicited assistance from FARC leadership in training an unsanctioned militia group that functioned, in essence, as an armed forces unit for the Cártel de Los Soles.

DEA’s Special Operations Division Bilateral Investigations Unit, New York Strike Force, and Miami Field Division conducted the investigation. This case is being handled by the U.S. Attorney’s Office for the Southern District of New York’s Terrorism and International Narcotics Unit. Assistant U.S. Attorneys Amanda L. Houle, Matthew J. Laroche, Jason A. Richman, and Kyle A. Wirshba are in charge of the prosecution.

* * *

An indictment unsealed today in the District of Columbia charges Vladimir Padrino Lopez, 56, Minister of Defense of Venezuela. The indictment alleges that from March 2014 until May 2019, Padrino Lopez conspired with others to distribute cocaine on board an aircraft registered in the United States.

Padrino Lopez, who holds the rank of General in the Venezuelan armed forces, held the authority for interdicting aircraft, many of which are registered in the United States, suspected of being used to traffic drugs from Venezuela to countries in Central America. On numerous occasions, Padrino Lopez ordered or authorized the Venezuelan military to force suspected trafficking aircraft to land or to shoot down the aircraft. However, Padrino Lopez allowed for other aircraft whose drug trafficking coordinators paid bribes to him to safely transit Venezuelan airspace.

On Sept. 25, 2018, the U.S. Department of the Treasury’s Office of Foreign Assets Control (OFAC) included Padrino Lopez on its Specially Designated Nationals List. Pursuant to the Foreign Narcotics Kingpin Designation Act, this means that his assets are blocked and U.S. persons are generally prohibited from having financial transactions with him.

The DEA Orlando District Office led the investigation, which was supported by the Organized Crime Drug Enforcement Task Force program and the Criminal Division’s Office of Enforcement Operations. Acting Deputy Chief Charles Miracle and Trial Attorneys Michael Christin and Kirt Marsh of the Criminal Division’s Narcotic and Dangerous Drug Section are prosecuting the case.

* * *

Maikel Jose Moreno Perez, 54, current Chief Justice of the Venezuelan Supreme Court, was charged via a criminal complaint in the Southern District of Florida with conspiracy to commit money laundering and money laundering in connection with the alleged corrupt receipt or intended receipt of tens of millions of dollars and bribes to illegally fix dozens of civil and criminal cases in Venezuela.

The complaint alleges, for example, that the defendant authorized a seizure and sale of a General Motors auto plant with an estimated value of $100 million in exchange for a personal percentage of the proceeds. Similarly, the complaint alleges that the defendant received bribes to authorize the dismissal of charges or release against Venezuelans, including one charged in a multibillion-dollar fraud scheme against the Venezuelan state-owned oil company.

According to the criminal complaint, in or around October 2014, Moreno Perez told U.S. authorities in a visa application that he earned the equivalent of about $12,000 per year from his work in Venezuela. From 2012 to 2016, the defendant’s U.S. bank records show approximately $3 million in inflows to the defendant’s accounts, primarily from large round-dollar transfers from shell corporations with foreign bank accounts linked to Co-Conspirator 1, who is a former criminal defense attorney in Venezuela that currently controls a media company in Venezuela.

As set out in the criminal complaint, the defendant’s bank records allegedly show that from 2012 to 2016, the defendant spent approximately $3 million, primarily in the geographical area of South Florida. For example, bank records allegedly show that Moreno Perez spent about $1 million for a private aircraft and private pilot, more than $600,000 in credit or debit card purchases at stores primarily in South Florida (including tens of thousands of dollars at luxury stores in Bal Harbor, such as Prada and Salvatore Ferragamo), about $50,000 in payments to a luxury watch repair store in Aventura, and approximately $40,000 in payments to a Venezuelan beauty pageant director.

HSI’s Miami Field Office conducted the investigation. Assistant U.S. Attorney Michael N. Berger of the Southern District of Florida is in charge of the prosecution.

* * *

A separate superseding indictment unsealed today in the Southern District of New York charges Tareck Zaidan El Aissami Maddah, 45, Venezuela’s vice president for the economy, Joselit Ramirez Camacho, 33, Venezuela’s superintendent of cryptocurrency (Sunacrip), and Samark Lopez Bello, 45, a Venezuelan businessman, with a series of crimes relating to efforts to evade sanctions imposed by OFAC against Maduro Moros, El Aissami Maddah, and Lopez Bello.

The indictment alleges that from February 2017 until March 2019, El Aissami Maddah and Ramirez Camacho worked with U.S. persons and U.S.-based entities to provide private flight services for the benefit of Maduro’s 2018 presidential campaign, in violation of OFAC’s sanctions targeting Maduro after he organized elections for the illegitimate National Constituent Assembly that Cabello Rondon now leads.

The U.S. Department of State, through its Narcotics Rewards Program, is offering a reward of up to $10 million for information leading to the arrest and/or conviction of El Aissami Maddah.

HSI’s New York Field Office conducted the investigation. This case is being handled by the U.S. Attorney’s Office for the Southern District of New York’s Terrorism and International Narcotics Unit. Assistant U.S. Attorneys Sam Adelsberg and Amanda L. Houle are in charge of the prosecution.

* * *

Other individuals charged in separate indictments include:

Luis Motta Dominguez, 67, Former Minister of Energy, was charged in the Southern District of Florida for his alleged role in laundering the proceeds of violations of the Foreign Corrupt Practices Act (FCPA) in connection with his alleged receipt of bribes to award Corpoelec business to U.S.-based companies;
Nestor Reverol Torres, 55, former General Director of Venezuela’s La Oficina Nacional Antidrogas (ONA) and former commander of Venezuela’s National Guard and Edylberto Jose Molina Molina, 57, former Sub-Director of Venezuela’s ONA and currently Venezuela’s military attaché to Germany, were charged in the Eastern District of New York with participating in an international cocaine distribution conspiracy where they allegedly assisted narcotics traffickers in importing cocaine into the United States;
Vassyly Kotosky Villarroel Ramirez aka “Mauro” and “Angel,” 47, a former captain in the Venezuelan Guardia Nacional, was charged in a third superseding indictment in the Eastern District of New York with participating in an international cocaine distribution conspiracy between Jan. 1, 2004, and Dec. 1, 2009;
Rafael Antonio Villasana Fernandez, 48, a former officer in the Venezuelan Guardia Nacional, was charged in the Eastern District of New York with participating in an international cocaine distribution conspiracy between Jan. 1, 2004, and Dec. 1, 2009. According to court documents, Kotosky and Villasana allegedly used official government vehicles to transport more than seven metric tons of cocaine from the Colombian border to various airports and seaports in Venezuela for ultimate importation into the United States;
Nervis Gerardo Villalobos Cardenas, 52, former Vice Minister of Energy of Venezuela, was charged in a 20-count indictment in the Southern District of Texas with conspiracy to commit money laundering, money laundering and conspiracy to violate the Foreign Corrupt Practices Act (FCPA) for his alleged role in an international money laundering scheme involving bribes paid by the owners of U.S.-based companies to Venezuelan government officials to corruptly secure energy contracts and payment priority on outstanding invoices; and
Oscar Rafael Colmenarez Villalobos, 51, former Venezuelan Air Force Officer, charged in the District of Arizona with violations of the Arms Export Control Act. He allegedly conspired with others, including individuals associated with an aviation company in Arizona, to smuggle from the United States to Venezuela T-76 military aircraft engines used on OV-10 Bronco aircraft to individuals in Venezuela and allegedly made false and misleading statements on shipping and export control documents to conceal the prohibited activities and transactions from detection of the U.S. government.

An indictment is merely an allegation and all defendants are presumed innocent until proven guilty beyond a reasonable doubt in a court of law.

IBM’s Watson Leading the Super Computer Charge on COVID-19

Posted on March 25, 2020March 25, 2020 by Denise Simon

Most missed the Trump White House announcement that on March 11th, the leaders of several tech companies met with the Trump team to discuss ways that super computers can process and speed up solutions for eradicating COVID-19 with treatment discoveries. On tap for the meeting, Facebook, Alphabet, Amazon, Twitter, Apple and Microsoft. The White House Chief Technology Officer, Michael Kratsios also enlisted the help of NASA, IBM, Oak Ridge National Laboratory, US Department of Energy, Argonne National Lab, Sandia National Laboratory, Lawrence Livermore National Lab, Los Alamos National Laboratory, The National Science Foundation, Massachusetts Institute of Technology, Rensselaer Polytechnic Institute and several others.

The COVID-19 High Performance Computing Consortium will bring significant computing power, 16 systems with over 330 petaflops, 775,000 CPU cores, and 34,000 GPUs to help researchers understand COVID-19 potential treatments and cures. “These high-performance computing systems allow researchers to run very large numbers of calculations in epidemiology, bioinformatics, and molecular modeling,” Dario Gil, director of IBM Research said in the announcement. “These experiments would take years to complete if worked by hand, or months if handled on slower, traditional computing platforms.”

“Since the start of COVID-19 pandemic we have been working closely with governments in the US and worldwide to find all available options to put our technology and expertise to work to help organizations be resilient and adapt to the consequences of the pandemic, and to accelerate the process of discovery and enable the scientific and medical community to develop treatments and ultimately a cure,” Gil said.

Powerful supercomputer and training program, IBM’s Summit, previously enabled researchers at the Oak Ridge National Laboratory and the University of Tennessee to screen nearly 8,000 compounds to uncover, which are most likely to bind to the main “spike” of the coronavirus, making it unable to reproduce and infect other cells.

The organizations were able to recommend 77 promising small-molecule drug compounds that could be experimentally tested. IBM will continue to work with different partners to evaluate proposals and provide access to supercomputing capacity to tackle to global pandemic.

“I am proud to be working with my IBM colleagues and the extended scientific community to help kick-start this effort. What began just two days ago with one conversation with the White House Office of Science and Technology Policy has solidified quickly into an unprecedented effort that can make a real difference,” Gil stressed.

***

The Oak Ridge National Laboratory in Tennessee (one member of the consortium) is using its supercomputers to look for compounds already on the market that might foil the virus.

Oak Ridge’s approach involves what’s called computational structure-based drug discovery. Basically, that means they use a computer to calculate how drugs might work against germs like viruses.

source

“We could get these calculations done in one day on the supercomputer, whereas a normal computer, it would take a month,” says Jeremy Smith, director of the Center for Molecular biophysics at Oak Ridge.

To run the calculations, you need to know the physical properties of the proteins a virus makes — what they’re made of and what their shape is.

One key viral protein of the coronavirus is called the spike protein. Information about what it looks like came out in mid-January, so Smith asked people in his lab if they wanted to start looking through databases of existing drugs that would block it.

***

Summit, IBM’s supercomputer equipped with the “brain of AI,” ran thousands of simulations to analyze which drug compounds might effectively stop the virus from infecting host cells.

The supercomputer identified 77 of them. It’s a promising step toward creating the most effective treatment.

Researchers at Oak Ridge National Laboratory published their findings in the journal ChemRxiv.

Summit was built to solve the world’s problems

Summit was commissioned by the US Department of Energy in 2014 for the purpose it’s serving now — solving the world’s problems.

It’s got the power of 200 petaflops, which means it has the computing speed of 200 quadrillion calculations per second, aka: It’s 1 million times more powerful than the fastest laptop.

Summit, the world’s most powerful supercomputer, modeled how different drug compounds might prevent the coronavirus from spreading to other cells.

At its station in Oak Ridge National Laboratory in Tennessee, Summit has identified patterns in cellular systems that precede Alzheimer’s, analyzed genes that contribute to traits like opioid addiction and predicted extreme weather based on climate simulations.

How Summit fights coronavirus

Viruses infect host cells by injecting them with a “spike” of genetic material. Summit’s job is to find drug compounds that could bind to that spike and potentially stop the spread.

Here’s a list of articles explaining the coronavirus pandemic

Oak Ridge researcher Micholas Smith created a model of the coronavirus spike based on research published in January. With Summit, he simulated how the atoms and particles in the viral protein would react to different compounds.

The supercomputer ran simulations of over 8,000 compounds that could bind to the spike protein of the virus, which could limit its ability to spread to host cells. Summit identified 77 of them and ranked them based on how likely they were to bind to the spike.

What’s next

The team will run the simulations on Summit again, using a more accurate model of the coronavirus’ spike that was published this month.

More here.

Hat tip to the Trump White House

Hey CNN/MSNBC for 15 Years, it has Been China’s SARS-CoV

Posted on March 23, 2020March 23, 2020 by Denise Simon

So, President Trump is right…how about media being real journalists for a change? Tell Hillary, CNN and the rest that Trump is hardly “racist” and “xenophobic”.

Let’s travel over to Basel, Switzerland shall we?

Primer: MDPI is Molecular Diversity Preservation International/Multidisciplinary Digital Publishing Institute founded in 1996 located in Basel. The organization is an open access repository of medical journals where each paper has citations from medical academics and experts. Health issues include various human health conditions such as obesity, autism, Alzheimer’s disease, cancer and many many others.

Image result for sar cov china

So, media, when it comes to China and SAR-CoV, review their summary. (BTW, it is full of citations)

1. Introduction

Fifteen years after the first highly pathogenic human coronavirus caused the severe acute respiratory syndrome coronavirus (SARS-CoV) outbreak, another severe acute diarrhea syndrome coronavirus (SADS-CoV) devastated livestock production by causing fatal diseases in pigs. Both outbreaks began in China and were caused by coronaviruses of bat origin [1,2]. This increased the urgency to study bat coronaviruses in China to understand their potential of causing another virus outbreak.

In this review, we collected information from past epidemiology studies on bat coronaviruses in China, including the virus species identified, their host species, and their geographical distributions. We also discuss the future prospects of bat coronaviruses cross-species transmission and spread in China.

2. Why Study Bat Coronaviruses in China?

2.1. Coronavirus Taxonomy

Coronaviruses (CoVs) belong to the subfamily Orthocoronavirinae in the family Coronaviridae and the order Nidovirales. CoVs have an enveloped, crown-like viral particle from which they were named after. The CoV genome is a positive-sense, single-strand RNA (+ssRNA), 27–32 kb in size, which is the second largest of all RNA virus genomes. Typically, two thirds of the genomic RNA encodes for two large overlapping polyproteins, ORF1a and ORF1b, that are processed into the viral polymerase (RdRp) and other nonstructural proteins involved in RNA synthesis or host response modulation. The other third of the genome encodes for four structural proteins (spike (S), envelope (E), membrane (M), and nucleocapsid (N)) and other accessory proteins. While the ORF1a/ORF1b and the four structural proteins are relatively consistent, the length of the CoV genome is largely dependent on the number and size of accessory proteins [3].

Compared with other RNA viruses, the expanded genome size of CoVs is believed to be associated with increased replication fidelity, after acquiring genes encoding RNA-processing enzymes [4]. Genome expansion further facilitates the acquisition of genes encoding accessory proteins that are beneficial for CoVs to adapt to a specific host [5]. As a result, genome changes caused by recombination, gene interchange, and gene insertion or deletion are common among CoVs. The CoV subfamily is expanding rapidly, due to the application of next generation sequencing which has increased the detection and identification of new CoV species. As a result, CoV taxonomy is constantly changing. According to the latest International Committee of Taxonomy of Viruses (ICTV) classification, there are four genera (α-, β-, δ-, and γ-) consisting of thirty-eight unique species in the subfamily [6]. The number of species will continue to increase, as there are still many unclassified CoVs [7,8].

CoVs cause disease in a variety of domestic and wild animals as well as in humans, where α- and β-CoVs mainly infect mammals and γ- and δ-CoVs mainly infect birds (Table 1). Two highly pathogenic β-CoVs, SARS-CoV, and MERS-CoV have caused pandemics in humans since 2002 [1,9]. Originating in China and then spreading to other parts of the world, SARS-CoV infected around 8000 individuals with an overall mortality of 10% during the 2002–2003 pandemic [1]. Since its emergence in 2012 in the Middle East, MERS-CoV spread to 27 countries, resulting in 2249 laboratory-confirmed cases of infection with an average mortality of 35.5% (until September 2018) [9]. Besides these two viruses, α-CoVs 229E and NL63 and β-CoVs OC43 and HKU1 can also cause respiratory diseases in humans [10]. Moreover, CoVs cause pandemic disease in domestic and wild animals (Table 1). SADS-CoV was recently identified as the etiological agent responsible for a large-scale outbreak of fatal disease in pigs in China that caused the death of more than 20,000 piglets [2]. Porcine epidemic diarrhea virus (PEDV) and transmissible gastroenteritis virus (TGEV) that belong to α-CoV and porcine δ-CoV (PDCoV) are also important emerging and re-emerging viruses in pigs that pose significant economic threat to the swine industry [11]. In addition, avian infectious bronchitis virus (IBV, γ-CoV) causes a highly contagious disease that affects poultry production worldwide [12]. Coronaviruses have also been associated with catarrhal gastroenteritis in mink (MCoV) and whale deaths (BWCoV-SW1) [13,14].

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