The Reason for the WH and Dr. Birx Chilling New Probability Report

Primer: We all seem to guess this except for Jim Acosta/CNN and the others at MSNBC. Media continues to blame the Trump White House for the slow response to address COVID-19, while Dr. Birx and Dr. Fauci explained what they did not know very early on. Now we know.

Now some real questions and new policy towards China must be considered. We can start with the $1.8 T in U.S. debt that China holds. The next is challenging American telecommunications companies to squelch China’s advances of 5G. Then there is the next phase of the U.S. trade agreement with China. Add in the mission to stop China’s power agenda across the globe as it is clear, China is fine with killing people and economies across the world.

China has concealed the extent of the coronavirus outbreak in its country, under-reporting both total cases and deaths it’s suffered from the disease, the U.S. intelligence community concluded in a classified report to the White House, according to three U.S. officials.

The officials asked not to be identified because the report is secret and declined to detail its contents. But the thrust, they said, is that China’s public reporting on cases and deaths is intentionally incomplete. Two of the officials said the report concludes that China’s numbers are fake.

The report was received by the White House last week, one of the officials said. The outbreak began in China’s Hubei province in late 2019, but the country has publicly reported only about 82,000 cases and 3,300 deaths, according to data compiled by Johns Hopkins University. That compares to more than 189,000 cases and more than 4,000 deaths in the U.S., which has the largest publicly reported outbreak in the world.

Communications staff at the White House and Chinese embassy in Washington didn’t immediately respond to requests for comment.

While China eventually imposed a strict lockdown beyond those of less autocratic nations, there has been considerable skepticism of China’s reported numbers, both outside and within the country. The Chinese government has repeatedly revised its methodology for counting cases, for weeks excluding people without symptoms entirely, and only on Tuesday added more than 1,500 asymptomatic cases to its total.

Stacks of thousands of urns outside funeral homes in Hubei province have driven public doubt in Beijing’s reporting.

Deborah Birx, the State Department immunologist advising the White House on its response to the outbreak, said Tuesday that China’s public reporting influenced assumptions elsewhere in the world about the nature of the virus.

Coronavirus: Doctor at hospital in China's Hubei province ... source

“The medical community made — interpreted the Chinese data as: This was serious, but smaller than anyone expected,” she said at a news conference on Tuesday. “Because I think probably we were missing a significant amount of the data, now that what we see happened to Italy and see what happened to Spain.”

China is not the only country with suspect public reporting. Western officials have pointed to Iran, Russia, Indonesia and especially North Korea, which has not reported a single case of the disease, as probable under-counts. Others including Saudi Arabia and Egypt may also be playing down their numbers.

U.S. Secretary of State Michael Pompeo has publicly urged China and other nations to be transparent about their outbreaks. He has repeatedly accused China of covering up the extent of the problem and being slow to share information, especially in the weeks after the virus first emerged, and blocking offers of help from American experts.

“This data set matters,” he said at a news conference in Washington on Tuesday. The development of medical therapies and public-health measures to combat the virus “so that we can save lives depends on the ability to have confidence and information about what has actually transpired,” he said.

“I would urge every nation: Do your best to collect the data. Do your best to share that information,” he said. “We’re doing that.”

The outbreak began in China’s Hubei province in late 2019, but the country has publicly reported only about 82,000 cases and 3,300 deaths, according to data compiled by Johns Hopkins University. That compares to more than 189,000 cases and more than 4,000 deaths in the U.S., which has the largest publicly reported outbreak in the world.

Map of sampling sites in the Hubei Province of China. Red ... source

 

Abstract

Background: The COVID-19 outbreak containment strategies in China based on non-pharmaceutical interventions (NPIs) appear to be effective. Quantitative research is still needed however to assess the efficacy of different candidate NPIs and their timings to guide ongoing and future responses to epidemics of this emerging disease across the World. Methods: We built a travel network-based susceptible-exposed-infectious-removed (SEIR) model to simulate the outbreak across cities in mainland China. We used epidemiological parameters estimated for the early stage of outbreak in Wuhan to parameterise the transmission before NPIs were implemented. To quantify the relative effect of various NPIs, daily changes of delay from illness onset to the first reported case in each county were used as a proxy for the improvement of case identification and isolation across the outbreak. Historical and near-real time human movement data, obtained from Baidu location-based service, were used to derive the intensity of travel restrictions and contact reductions across China. The model and outputs were validated using daily reported case numbers, with a series of sensitivity analyses conducted. Results: We estimated that there were a total of 114,325 COVID-19 cases (interquartile range [IQR] 76,776 – 164,576) in mainland China as of February 29, 2020, and these were highly correlated (p<0.001, R2=0.86) with reported incidence. Without NPIs, the number of COVID-19 cases would likely have shown a 67-fold increase (IQR: 44 – 94), with the effectiveness of different interventions varying. The early detection and isolation of cases was estimated to prevent more infections than travel restrictions and contact reductions, but integrated NPIs would achieve the strongest and most rapid effect. If NPIs could have been conducted one week, two weeks, or three weeks earlier in China, cases could have been reduced by 66%, 86%, and 95%, respectively, together with significantly reducing the number of affected areas. However, if NPIs were conducted one week, two weeks, or three weeks later, the number of cases could have shown a 3-fold, 7-fold, and 18-fold increase across China, respectively. Results also suggest that the social distancing intervention should be continued for the next few months in China to prevent case numbers increasing again after travel restrictions were lifted on February 17, 2020. Conclusion: The NPIs deployed in China appear to be effectively containing the COVID-19 outbreak, but the efficacy of the different interventions varied, with the early case detection and contact reduction being the most effective. Moreover, deploying the NPIs early is also important to prevent further spread. Early and integrated NPI strategies should be prepared, adopted and adjusted to minimize health, social and economic impacts in affected regions around the World.

 

IBM’s Watson Leading the Super Computer Charge on COVID-19

Most missed the Trump White House announcement that on March 11th, the leaders of several tech companies met with the Trump team to discuss ways that super computers can process and speed up solutions for eradicating COVID-19 with treatment discoveries. On tap for the meeting, Facebook, Alphabet, Amazon, Twitter, Apple and Microsoft. The White House Chief Technology Officer, Michael Kratsios also enlisted the help of NASA, IBM, Oak Ridge National Laboratory, US Department of Energy, Argonne National Lab, Sandia National Laboratory, Lawrence Livermore National Lab, Los Alamos National Laboratory, The National Science Foundation, Massachusetts Institute of Technology, Rensselaer Polytechnic Institute and several others.

The COVID-19 High Performance Computing Consortium will bring significant computing power, 16 systems with over 330 petaflops, 775,000 CPU cores, and 34,000 GPUs to help researchers understand COVID-19 potential treatments and cures. “These high-performance computing systems allow researchers to run very large numbers of calculations in epidemiology, bioinformatics, and molecular modeling,” Dario Gil, director of IBM Research said in the announcement. “These experiments would take years to complete if worked by hand, or months if handled on slower, traditional computing platforms.”

“Since the start of COVID-19 pandemic we have been working closely with governments in the US and worldwide to find all available options to put our technology and expertise to work to help organizations be resilient and adapt to the consequences of the pandemic, and to accelerate the process of discovery and enable the scientific and medical community to develop treatments and ultimately a cure,” Gil said.

Powerful supercomputer and training program, IBM’s Summit, previously enabled researchers at the Oak Ridge National Laboratory and the University of Tennessee to screen nearly 8,000 compounds to uncover, which are most likely to bind to the main “spike” of the coronavirus, making it unable to reproduce and infect other cells.

The organizations were able to recommend 77 promising small-molecule drug compounds that could be experimentally tested.  IBM will continue to work with different partners to evaluate proposals and provide access to supercomputing capacity to tackle to global pandemic.

“I am proud to be working with my IBM colleagues and the extended scientific community to help kick-start this effort. What began just two days ago with one conversation with the White House Office of Science and Technology Policy has solidified quickly into an unprecedented effort that can make a real difference,” Gil stressed.

***

The Oak Ridge National Laboratory in Tennessee (one member of the consortium) is using its supercomputers to look for compounds already on the market that might foil the virus.

Oak Ridge’s approach involves what’s called computational structure-based drug discovery. Basically, that means they use a computer to calculate how drugs might work against germs like viruses.

“We could get these calculations done in one day on the supercomputer, whereas a normal computer, it would take a month,” says Jeremy Smith, director of the Center for Molecular biophysics at Oak Ridge.

To run the calculations, you need to know the physical properties of the proteins a virus makes — what they’re made of and what their shape is.

One key viral protein of the coronavirus is called the spike protein. Information about what it looks like came out in mid-January, so Smith asked people in his lab if they wanted to start looking through databases of existing drugs that would block it.

***

Summit, IBM’s supercomputer equipped with the “brain of AI,” ran thousands of simulations to analyze which drug compounds might effectively stop the virus from infecting host cells.
The supercomputer identified 77 of them. It’s a promising step toward creating the most effective treatment.
Researchers at Oak Ridge National Laboratory published their findings in the journal ChemRxiv.

Summit was built to solve the world’s problems

Summit was commissioned by the US Department of Energy in 2014 for the purpose it’s serving now — solving the world’s problems.
It’s got the power of 200 petaflops, which means it has the computing speed of 200 quadrillion calculations per second, aka: It’s 1 million times more powerful than the fastest laptop.Summit, the world&#39;s most powerful supercomputer, modeled how different drug compounds might prevent the coronavirus from spreading to other cells.

At its station in Oak Ridge National Laboratory in Tennessee, Summit has identified patterns in cellular systems that precede Alzheimer’s, analyzed genes that contribute to traits like opioid addiction and predicted extreme weather based on climate simulations.

How Summit fights coronavirus

Viruses infect host cells by injecting them with a “spike” of genetic material. Summit’s job is to find drug compounds that could bind to that spike and potentially stop the spread.
Oak Ridge researcher Micholas Smith created a model of the coronavirus spike based on research published in January. With Summit, he simulated how the atoms and particles in the viral protein would react to different compounds.
The supercomputer ran simulations of over 8,000 compounds that could bind to the spike protein of the virus, which could limit its ability to spread to host cells. Summit identified 77 of them and ranked them based on how likely they were to bind to the spike.

What’s next

The team will run the simulations on Summit again, using a more accurate model of the coronavirus’ spike that was published this month.Why these volunteers chose to participate in a coronavirus vaccine trial

Hat tip to the Trump White House

 

Democrats Counter-proposal for Covid Stimulus Spending

The disgusting political pork, poison politics on full display. If for nothing else, we have learned another level of the nasty appropriations injected into crisis spending. This should never be overlooked or forgotten as we go to vote.
If you can stand to read the Democrats 1119 page fleecing of the taxpayer, click here.

If not, here is the Cliff note list which is hardly all of the items, but you get the idea:

  • $33,200,000 for NOAA to get new facilities for operations and research
  • $100,000,000 for NASA and $100,000,000 for construction and compliance
  • $278,000,000 to the IRS for taxpayer services
  • $90,000,000 for yet another HIV program
  • $36,000,000 for the National Center for Advancing Translational Sciences
  • $7,000,000 for one, ONE Washington DC Charter School called Gallaudet University
  • $23,000,000 handout to Howard University AND $647,000,000 endowment to Howard University
  • $300,000,000 to the Corporation for Public Broadcasting
  • $500,000,000 for the Institute of Museum and Library Services
  • $1,000,000 for the Senate Sergeant at Arms and the Doorkeeper of the Senate
  • $300,000,000 for Migration and Refugee Assistance
  • $22,000,000 for the Expansion of Use of Minority Banks and Minority Credit Unions
  • $300,000,000 to Expand Emergency Food Assistance Programs
  • $40,000,000 for a new division, the Oversight and Accountability Transparency Committee dedicated to coronavirus
  • $35,000,000 for the John F. Kennedy Center for the Performing Arts
  • $300,000,000 National Endowment of the Arts
  • $300,000,000 for National Endowment of the Humanities

Add in the following as noted by Senator Tom Cotton (R-Arkansas)

  • Removing all current debt of the US Postal Service
  • Monies for more REQUIRED early voting, same day voter registration AND registering to vote abilities via internet registration
  • Removing off the top $10,000 for every person holding a student loan
  • Any U.S. corporation accepting Federal government assistance must have 1/3 of their Board members chosen by their own emloyees
  • Additional provisions for official time for union collective bargaining
  • Full offset of airline emissions by 2025
  • Each airline flight must report greenhouse gas statistics (carbon output) of individual flights
  • Retirement benefits for community newspaper employees
  • Any and all corporations accepting Federal government assistance must pay all employees a minimum wage of $15/hr.
  • Permanent paid leave for all corporations receiving Federal assistance
  • Expansion of wind and solar tax credits
  • Election Assistance Commission

Now understand how the items referring to domestic corporations is actually a quid pro quo or rather extortion or rather nationalizing corporations in America.

Now this list, while being somewhat abbreviated, is not something just recently concocted by Democrats for this pending spending bill…consider these are items that have been sitting on the wish list for quite some time and these items are just like those that get injected into spending legislation all the time at the last minute when members of Congress get 30 minutes or less to read bills before they vote.

Pelosi’s $2.5 Trillion Virus Bill Delays Mortgage, Car Payments source and more details here

For those in the many domestic industries affected by being shuttered due to governor decrees, remember the hold up in financial stability, jobs and loans sits squarely in the lap of the Democrats led completely by the master legislator…Speaker Nancy Pelosi, third in line to the presidency. Scary….no terrifying.

 

Hey CNN/MSNBC for 15 Years, it has Been China’s SARS-CoV

So, President Trump is right…how about media being real journalists for a change? Tell Hillary, CNN and the rest that Trump is hardly “racist” and “xenophobic”.

Let’s travel over to Basel, Switzerland shall we?

Primer: MDPI is Molecular Diversity Preservation International/Multidisciplinary Digital Publishing Institute founded in 1996 located in Basel. The organization is an open access repository of medical journals where each paper has citations from medical academics and experts. Health issues include various human health conditions such as obesity, autism, Alzheimer’s disease, cancer and many many others.

Image result for sar cov china

So, media, when it comes to China and SAR-CoV, review their summary. (BTW, it is full of citations)

1. Introduction

Fifteen years after the first highly pathogenic human coronavirus caused the severe acute respiratory syndrome coronavirus (SARS-CoV) outbreak, another severe acute diarrhea syndrome coronavirus (SADS-CoV) devastated livestock production by causing fatal diseases in pigs. Both outbreaks began in China and were caused by coronaviruses of bat origin [1,2]. This increased the urgency to study bat coronaviruses in China to understand their potential of causing another virus outbreak.
In this review, we collected information from past epidemiology studies on bat coronaviruses in China, including the virus species identified, their host species, and their geographical distributions. We also discuss the future prospects of bat coronaviruses cross-species transmission and spread in China.

2. Why Study Bat Coronaviruses in China?

2.1. Coronavirus Taxonomy

Coronaviruses (CoVs) belong to the subfamily Orthocoronavirinae in the family Coronaviridae and the order Nidovirales. CoVs have an enveloped, crown-like viral particle from which they were named after. The CoV genome is a positive-sense, single-strand RNA (+ssRNA), 27–32 kb in size, which is the second largest of all RNA virus genomes. Typically, two thirds of the genomic RNA encodes for two large overlapping polyproteins, ORF1a and ORF1b, that are processed into the viral polymerase (RdRp) and other nonstructural proteins involved in RNA synthesis or host response modulation. The other third of the genome encodes for four structural proteins (spike (S), envelope (E), membrane (M), and nucleocapsid (N)) and other accessory proteins. While the ORF1a/ORF1b and the four structural proteins are relatively consistent, the length of the CoV genome is largely dependent on the number and size of accessory proteins [3].
Compared with other RNA viruses, the expanded genome size of CoVs is believed to be associated with increased replication fidelity, after acquiring genes encoding RNA-processing enzymes [4]. Genome expansion further facilitates the acquisition of genes encoding accessory proteins that are beneficial for CoVs to adapt to a specific host [5]. As a result, genome changes caused by recombination, gene interchange, and gene insertion or deletion are common among CoVs. The CoV subfamily is expanding rapidly, due to the application of next generation sequencing which has increased the detection and identification of new CoV species. As a result, CoV taxonomy is constantly changing. According to the latest International Committee of Taxonomy of Viruses (ICTV) classification, there are four genera (α-, β-, δ-, and γ-) consisting of thirty-eight unique species in the subfamily [6]. The number of species will continue to increase, as there are still many unclassified CoVs [7,8].
CoVs cause disease in a variety of domestic and wild animals as well as in humans, where α- and β-CoVs mainly infect mammals and γ- and δ-CoVs mainly infect birds (Table 1). Two highly pathogenic β-CoVs, SARS-CoV, and MERS-CoV have caused pandemics in humans since 2002 [1,9]. Originating in China and then spreading to other parts of the world, SARS-CoV infected around 8000 individuals with an overall mortality of 10% during the 2002–2003 pandemic [1]. Since its emergence in 2012 in the Middle East, MERS-CoV spread to 27 countries, resulting in 2249 laboratory-confirmed cases of infection with an average mortality of 35.5% (until September 2018) [9]. Besides these two viruses, α-CoVs 229E and NL63 and β-CoVs OC43 and HKU1 can also cause respiratory diseases in humans [10]. Moreover, CoVs cause pandemic disease in domestic and wild animals (Table 1). SADS-CoV was recently identified as the etiological agent responsible for a large-scale outbreak of fatal disease in pigs in China that caused the death of more than 20,000 piglets [2]. Porcine epidemic diarrhea virus (PEDV) and transmissible gastroenteritis virus (TGEV) that belong to α-CoV and porcine δ-CoV (PDCoV) are also important emerging and re-emerging viruses in pigs that pose significant economic threat to the swine industry [11]. In addition, avian infectious bronchitis virus (IBV, γ-CoV) causes a highly contagious disease that affects poultry production worldwide [12]. Coronaviruses have also been associated with catarrhal gastroenteritis in mink (MCoV) and whale deaths (BWCoV-SW1) [13,14].

Read on here if you need to.

Wonder if candidate Joe Biden or Bernie Sanders will reveal this as truth in their ad attacks?

(PanCAP)SynchronizationMatrix-COVID-19 Plan

The Defense Production Act. Read it here.

The president invoked the act Wednesday during a White House news briefing with members of the Coronavirus Task Force.

“It can do a lot of good things if we need it,” the president told reporters.

Image result for defense production act source

 

The 1950 act was periodically used during both the Korean War and throughout the Cold War, and was last invoked in June 2017 by Trump to provide technology in the space industrial base.

This is not about what the Federal government can provide, but rather the Federal government authorizing and hiring private business to produce products and service to fulfill the needs for the good of the nation. That is where innovation and capitalism works.

President Trump is pulling all the levers of government and plowing his way through regulations and bureaucracy. It is big and messy mostly because of Obamacare which installed 23000 pages of regulations. The PANCAP plan is found here in full. Additional levers are being created to stop the economic and financial damage the the nation.

Meanwhile, media has attacked President Trump for using the term ‘China virus’ and he defended that use, rightly so. The medical community uses several variations of the same phrase. It is about China and has been for decades. World leaders have challenged China for countless years over their reckless laws and lack of food, people, animal and health protections. I have seen it personally myself being in mainland China many years ago. I visited those wet markets where the food supply and lack of safety is not only disgusting but deadly. Truth be told, trafficking and breeding animals for food in China is estimated to be a $76 billion industry.

For perspective, this short video is a must watch.

Relations between the West and China has taken on a new attitude and approach and rightly so. The discussions should begin with China paying trillions in reparations to nations affected by not only the Covid-19 virus but even previous virus outbreaks as well. China holds an estimated $1.7 trillion of U.S. debt. China should forgive that debt today.

From an article written by Michael Auslin in part mentions:

Those concerned with global health issues may wonder why it is that China is wracked regularly by viral epidemics in addition to coronavirus, such as SARS, African Swine Fever, and avian flu (another outbreak is happening right now). Others may begin to look more carefully at China’s environmental devastation and the hundreds of thousands of premature deaths each year from air and water pollution.

On the trade side, many foreign corporations already have been reconsidering their operations in China, due to rampant intellectual property theft and rising production costs; now, they may seriously question how safe it is to continue to do business in China. Not only is the health of their employees at risk, but they no longer can be assured that China will be a stable supplier. If coronavirus becomes a seasonal phenomenon, as some experts predict, then even with a vaccine, new strains of the pathogen will always raise the specter of another out-of-control epidemic overwhelming the party-state’s capabilities and infecting the rest of the world.

China has a plan to be the world’s dominant power, what better way to achieve that mission than to infect the globe with a pandemic causing financial collapse? To prevent the China mission, Western nations must reassert nationalism including manufacturing and install policy that never allows vulnerabilities to health and national security, this includes 5G. China and Russia cannot be allowed to win much less have any kind of advantage over other nations.

U.S. citizens are very crafty, innovative and resourceful and given these skills and spirit, this will pass quickly.